Single nanowire memory units are of particular interest in the design of high-density nanoelectronic circuits, but the performance due to weak contact state remains a major problem. In this paper, bonding between core/shell SiC/SiO2 nanowire and Au electrodes can be improved via local contact engineering with femtosecond (fs) laser irradiation. An optimized heterojunction (Au-SiO2-SiC) is possible since plasmonic enhanced optical absorption can be localized at the metal-oxide (Au-SiO2) interface. Electron transport across the barrier and charge accumulation at the oxide-semiconductor (SiO2-SiC) interface are improved in nanowire circuits. A fast and stable resistance change can be achieved after only one biasing cycle ('write') and the written state can be read/extracted at a low voltage (? 0.5 V). Unlike other as-built nanowire circuits, the resistance state can be retained for 10 min in the absence of external power, indicating that these devices can be used for short-term memory units. https://www.selleckchem.com/products/lithium-chloride.html High current tolerance is also provided in the circuit by the surface oxide shell which acts to protect the inner SiC core. The current density carried by the single SiC/SiO2 nanowire circuit can be as high as ?3 × 106 A cm-2 before break down, and that breakdown occurs as a two-stage process.A CoCrFeNiMn high entropy alloy with a novel nanostructure consisting of ultrafine grains, TiO(C) nanoparticles and nanotwins has been fabricated. It achieves an ultrahigh tensile yield strength of 1507 MPa by coupling multiple strengthening mechanisms, including grain boundary strengthening, twin boundary strengthening, nanoparticle strengthening and dislocation strengthening. The work hardening ability is also improved by coupling the interactions of dislocations with nanoparticles and nanotwins during plastic deformation, leading to a good tensile ductility with a uniform elongation of 4.7%.Base-catalyzed, C-alkylation of potassium (K) enolates with styrenes (CAKES) has recently emerged as a highly practical and convenient method for elaboration or synthesis of pharmaceutically-relevant cores. K enolate-type precursors such as alkyl-substituted heterocycles (pyridines, pyrazines and thiophenes), ketones, imines, nitriles and amides undergo C-alkylation reactions with styrene in the presence of KOtBu or KHMDS. Surprisingly, no studies have probed the reaction mechanism beyond the likely initial formation of a K enolate. Herein, a synergistic approach of computational (DFT), kinetic and deuterium labelling studies rationalizes various experimental observations and supports a metal-ene-type reaction for amide CAKES. Moreover, our approach explains experimental observations in other reported C-alkylation reactions of other enolate-type precursors, thus implicating a general mechanism for CAKES.As one of the most promising noninvasive therapeutic modalities, sonodynamic therapy (SDT) can focus the ultrasound energy on tumor sites located in deep tissue and locally activate the preloaded sonosensitizer to kill tumor cells. However, exploring sonosensitizers with high SDT efficacy and desirable biosafety is still a significant challenge. Herein, we utilized the hydrophilic-hydrophobic self-assembly technology to assemble the hydrophobic organic dye Ce6 and broad spectral anti-cancer agent Paclitaxel with hydrophilic organic dye IR783 to generate a nanoscale sonosensitizer, Ce6-PTX@IR783, without the introduction of extra nanomaterials into the fabrication to guarantee high therapeutic biosafety and further potential clinical translation. The constructed nanodrug was endowed with an external ultrasound-activatable chemo-sonodynamic effect and photoacoustic imaging performance via integrating multiple moieties into one nanosystem. Ce6 could enhance the sonodynamic effect, while PTX exerted a chemotherapeutic effect, and IR783 was applied to increase tumor-specific accumulation and assist in fulfilling photoacoustic imaging. In particular, the small particle size (70 nm) of Ce6-PTX@IR783 contributed to the increased tumor accumulation via the enhanced permeability and retention effect. The high synergistically chemo-sonodynamic therapeutic efficacy has been successfully demonstrated in vitro and in vivo, in addition to the demonstrated high biodegradability, biocompatibility and biosafety. This facile self-assembly procedure provides an intriguing strategy for highly efficient utilization of hydrophobic drugs and is liable to realize large-scale production and further clinical translation.High aspect ratio nanostructuring requires high precision pattern transfer with highly directional etching. In this work, we demonstrate the fabrication of structures with ultra-high aspect ratios (up to 10?000??1) in the nanoscale regime (down to 10 nm) by platinum assisted chemical etching of silicon in the gas phase. The etching gas is created by a vapour of water diluted hydrofluoric acid and a continuous air flow, which works both as an oxidizer and as a gas carrier for reactive species. The high reactivity of platinum as a catalyst and the formation of platinum silicide to improve the stability of the catalyst pattern allow a controlled etching. The method has been successfully applied to produce straight nanowires with section size in the range of 10-100 nm and length of hundreds of micrometres, and X-ray optical elements with feature sizes down to 10 nm and etching depth in the range of tens of micrometres. This work opens the possibility of a low cost etching method for stiction-sensitive nanostructures and a large range of applications where silicon high aspect ratio nanostructures and high precision of pattern transfer are required.Nanodiamonds are increasingly used in many areas of science and technology, yet, their colloidal properties remain poorly understood. Here we use direct imaging as well as light and X-ray scattering reveal that purified detonation nanodiamond (DND) particles in an aqueous environment exhibit a self-assembled lace-like network, even without additional surface modification. Such behaviour is previously unknown and contradicts the current consensus that DND exists as mono-dispersed single particles. With the aid of mesoscale simulations, we show that the lace network is likely the result of competition between a short-ranged electrostatic attraction between faceted particles and a longer-ranged repulsion arising from the interaction between the surface functional groups and the surrounding water molecules which prevents complete flocculation. Our findings have significant implications for applications of DND where control of the aggregation behaviour is critical to performance.